Altered IgA Response to Gut Bacteria Is Associated with Childhood Asthma in Peru.

ABSTRACT: Alterations in gut microbiota in early life have been associated with the development of asthma; however, the role of gut bacteria or the IgA response to gut bacteria in school-aged children with asthma is unclear. To address this question, we profiled the microbial populations in fecal and nasal swab samples by 16S rRNA sequencing from 40 asthma and 40 control children aged 9-17 y from Peru. Clinical history and laboratory evaluation of asthma and allergy were obtained. Fecal samples were analyzed by flow cytometry and sorted into IgA⁺ and IgA^- subsets for 16S rRNA sequencing. We found that the fecal or nasal microbial 16S rRNA diversity and frequency of IgA⁺ fecal bacteria did not differ between children with or without asthma. However, the α diversity of

SUBMITTER: Hsieh CS 

PROVIDER: S-EPMC8516662 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature