Pinching and pushing: fold formation in the Drosophila dorsal epidermis.

ABSTRACT: Epithelial folding is a fundamental morphogenetic process that shapes planar epithelial sheets into complex three-dimensional structures. Multiple mechanisms can generate epithelial folds, including apical constriction, which acts locally at the cellular level, differential growth on the tissue scale, or buckling because of compression from neighboring tissues. Here, we investigate the formation of dorsally located epithelial folds at segment boundaries during the late stages of Drosophila embryogenesis. We found that the fold formation at the segment boundaries occurs through the juxtaposition of two key morphogenetic processes: local apical constriction and tissue-level compressive forces from posterior segments. Further, we found that epidermal spreading and fold formation are accompani

SUBMITTER: Velagala V 

PROVIDER: S-EPMC8516683 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature