Brain imaging of cannabinoid type I (CB₁ ) receptors in women with cannabis use disorder and male and female healthy controls.

ABSTRACT: Cannabis effects are predominantly mediated by pharmacological actions on cannabinoid type 1 (CB₁ ) receptors. Prior positron emission tomography (PET) studies in individuals who use cannabis included almost exclusively males. PET studies in females are needed because there are sex differences in cannabis effects, progression to cannabis use disorder (CUD), and withdrawal symptom severity. Females with CUD (N = 10) completed two double-blind cannabis smoking sessions (Session 1: placebo; Session 2: active), and acute cannabis effects were assessed. After Session 2, participants underwent 3 days of monitored cannabis abstinence; mood, craving, and withdrawal symptoms were assessed and a PET scan (radiotracer: [¹¹ C]OMAR) followed. [¹¹ C]OMAR Distribution vol

SUBMITTER: Spindle TR 

PROVIDER: S-EPMC8516687 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature