Bacterial Vaginosis-Associated Bacteria and Uterine Fibroids: A Nested Case-Control Study.

ABSTRACT:

Background

Reproductive tract infections are hypothesized to influence uterine fibroid development, yet few studies have investigated the common condition of bacterial vaginosis (BV). The literature is currently limited to data using self-report of BV.

Methods

We conducted a nested case-control study of 200 women (100 cases and 100 controls) from a large study of 23- to 35-year-old African American women, 1310 of whom were fibroid-free and prospectively followed up for 5 years to identify incident fibroids with standardized ultrasound examinations. We used quantitative polymerase chain reaction, an objective molecular method, to assess 9 BV-associated and 4 Lactobacillus species from vaginal swab specimens. We used hierarchical logistic regression to compute odds ratios and

SUBMITTER: Moore KR 

PROVIDER: S-EPMC8516695 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature