Evolving biological associations of upfront cytoreductive nephrectomy in metastatic renal cell carcinoma.

ABSTRACT:

Background

Systemic responses to cytoreductive nephrectomy (CN) in the management of metastatic renal cell carcinoma (mRCC) are variable and difficult to anticipate. The authors aimed to determine the association of CN with modifiable International Metastatic Renal Cell Carcinoma Database Consortium (IMDC) risk factors and oncological outcomes.

Methods

Consecutive patients with mRCC referred for potential CN (2009-2019) were reviewed. The primary outcome was overall survival (OS); variables of interest included undergoing CN and the baseline number of modifiable IMDC risk factors (anemia, hypercalcemia, neutrophilia, thrombocytosis, and reduced performance status). For operative cases, the authors evaluated the effects of IMDC risk factor dynamics, measured 6 weeks and 6 mon

SUBMITTER: Silagy AW 

PROVIDER: S-EPMC8516697 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature