Ontology highlight
ABSTRACT:
SUBMITTER: Hossain AA
PROVIDER: S-EPMC8516739 | biostudies-literature | 2021 Oct
REPOSITORIES: biostudies-literature
Hossain Amer A AA McGinn Jon J Meeske Alexander J AJ Modell Joshua W JW Marraffini Luciano A LA
Cell host & microbe 20210927 10
CRISPR-Cas systems provide immunity to bacteria by programing Cas nucleases with RNA guides that recognize and cleave infecting viral genomes. Bacteria and their viruses each encode recombination systems that could repair the cleaved viral DNA. However, it is unknown whether and how these systems can affect CRISPR immunity. Bacteriophage λ uses the Red system (gam-exo-bet) to promote recombination between related phages. Here, we show that λ Red also mediates evasion of CRISPR-Cas targeting. Gam ...[more]