An fMRI study of cognitive reappraisal in major depressive disorder and borderline personality disorder.

ABSTRACT:

Background

One common denominator to the clinical phenotypes of borderline personality disorder (BPD) and major depressive disorder (MDD) is emotion regulation impairment. Although these two conditions have been extensively studied separately, it remains unclear whether their emotion regulation impairments are underpinned by shared or distinct neurobiological alterations.

Methods

We contrasted the neural correlates of negative emotion regulation across an adult sample of BPD patients (n = 19), MDD patients (n = 20), and healthy controls (HCs; n = 19). Emotion regulation was assessed using an established functional magnetic resonance imaging cognitive reappraisal paradigm. We assessed both task-related activations and modulations of interregional connectivity.

Results

SUBMITTER: De la Pena-Arteaga V 

PROVIDER: S-EPMC8516744 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature