Histone deacetylase (HDAC) 9: versatile biological functions and emerging roles in human cancer.

ABSTRACT:

Background

HDAC9 (histone deacetylase 9) belongs to the class IIa family of histone deacetylases. This enzyme can shuttle freely between the nucleus and cytoplasm and promotes tissue-specific transcriptional regulation by interacting with histone and non-histone substrates. HDAC9 plays an essential role in diverse physiological processes including cardiac muscle development, bone formation, adipocyte differentiation and innate immunity. HDAC9 inhibition or activation is therefore a promising avenue for therapeutic intervention in several diseases. HDAC9 overexpression is also common in cancer cells, where HDAC9 alters the expression and activity of numerous relevant proteins involved in carcinogenesis.

Conclusions

This review summarizes the most recent discoveries regarding

SUBMITTER: Yang C 

PROVIDER: S-EPMC8516780 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature