Development of a Novel Endovascular Brachytherapy Stent: A Proof-of-concept Study.

ABSTRACT:

Background and aims

Endovascular implantation of iodine-125 (¹²⁵I) seeds strand combined with stent is an effective method of treatment for portal vein tumor thrombosis. The aim of this study was to develop a novel endovascular brachytherapy stent (EVB-Stent) and to evaluate its feasibility of use.

Methods

An EVB-Stent was implanted into the main portal vein (MPV) in a live porcine model via the percutaneous transhepatic route. Blood samples were collected and tested before and after operation, as well as before euthanasia. Single-photon emission computed tomography (SPECT) combined with CT (SPECT/CT) scan were performed directly after operation and CT scan was performed 2 months after implantation. After the CT scan was performed, all animals were euthanized and

SUBMITTER: Du N 

PROVIDER: S-EPMC8516836 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature