Novel Agents in the Management of Hepatic Encephalopathy: A Review.

ABSTRACT: Hepatic encephalopathy is an often devastating complication of chronic liver disease, associated with high mortality and increased burden on patients and healthcare systems. Current agents (such as nonabsorbable disaccharides and oral antibiotics) are often only partially effective and associated with unpleasant side effects. With our improved understanding of the pathophysiology of hepatic encephalopathy, multiple treatment modalities have emerged with promising results when used alone or as an adjunct to standard medications. The mechanisms of these agents vary greatly, and include the manipulation of gut microbial composition, reduction of oxidative stress, inhibition of inflammatory mediators, protection of endothelial integrity, modulation of neurotransmitter release and function, and

SUBMITTER: Hasan LZ 

PROVIDER: S-EPMC8516841 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature