Serum N-terminal DDR1: A Novel Diagnostic Marker of Liver Fibrosis Severity.

ABSTRACT:

Background and aims

The expression of discoidin domain receptor 1 (DDR1) is commonly up-regulated and undergoes collagen-induced ectodomain (N-terminal) shedding during the progression of liver fibrosis. This study aimed to evaluate the clinical utility of N-terminal DDR1 as a diagnostic biomarker for liver fibrosis.

Methods

N-terminal DDR1 shedding was evaluated using cell lines, liver fibrosis mouse models, clinical data of 298 patients collected from February 2019 to June 2020. The clinical data were divided into test and validation cohorts to evaluate the diagnostic performance of serum N-terminal DDR1.

Results

Time- and dosage-dependent N-terminal DDR1 shedding stimulated by collagen I was observed in a hepatocyte cell line model. The type I collagen deposition a

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC8516844 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature