Targeting the complex I and III of mitochondrial electron transport chain as a potentially viable option in liver cancer management.

ABSTRACT: Liver cancer is one of the most common and lethal types of oncological disease in the world, with limited treatment options. New treatment modalities are desperately needed, but their development is hampered by a lack of insight into the underlying molecular mechanisms of disease. It is clear that metabolic reprogramming in mitochondrial function is intimately linked to the liver cancer process, prompting the possibility to explore mitochondrial biochemistry as a potential therapeutic target. Here we report that depletion of mitochondrial DNA, pharmacologic inhibition of mitochondrial electron transport chain (mETC) complex I/complex III, or genetic of mETC complex I restricts cancer cell growth and clonogenicity in various preclinical models of liver cancer, including cell lines, mouse li

SUBMITTER: Yang Q 

PROVIDER: S-EPMC8516882 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature