Influence of PICALM and CLU risk variants on beta EEG activity in Alzheimer's disease patients.

ABSTRACT: PICALM and CLU genes have been linked to alterations in brain biochemical processes that may have an impact on Alzheimer's disease (AD) development and neurophysiological dynamics. The aim of this study is to analyze the relationship between the electroencephalographic (EEG) activity and the PICALM and CLU alleles described as conferring risk or protective effects on AD patients and healthy controls. For this purpose, EEG activity was acquired from: 18 AD patients and 12 controls carrying risk alleles of both PICALM and CLU genes, and 35 AD patients and 12 controls carrying both protective alleles. Relative power (RP) in the conventional EEG frequency bands (delta, theta, alpha, beta, and gamma) was computed to quantify the brain activity at source level. In addition, spatial entropy (SE)

SUBMITTER: Maturana-Candelas A 

PROVIDER: S-EPMC8516883 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature