Loss of TRIM31 promotes breast cancer progression through regulating K48- and K63-linked ubiquitination of p53.

ABSTRACT: Breast cancer is the most common cancer in the world. Relapse and metastasis are important factors endangering the life of breast cancer patients, but the mechanism is still unclear. The stabilization of p53 is essential for preventing carcinogenesis, and ubiquitination is one of the main ways to regulate the stability of p53. Tripartite motif-containing 31 (TRIM31) is a new member of the TRIM family and functions as an E3 ubiquitin ligase. It acts as a cancer promoter or suppressor in the malignant processes of multiple cancers. However, the function of TRIM31 in breast cancer progression remains unknown. In this study, we showed that TRIM31 is downregulated in breast cancer tissues and negatively correlated with breast cancer progression. Both gain- and loss-of-function assays indicated

SUBMITTER: Guo Y 

PROVIDER: S-EPMC8516922 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature