MiR-223-3p and miR-24-3p as novel serum-based biomarkers for myotonic dystrophy type 1.

ABSTRACT: Myotonic dystrophy type 1 (DM1) is the most common adult-onset muscular dystrophy, primarily characterized by muscle wasting and weakness. Many biomarkers already exist in the rapidly developing biomarker research field that aim to improve patients' care. Limited work, however, has been performed on rare diseases, including DM1. We have previously shown that specific microRNAs (miRNAs) can be used as potential biomarkers for DM1 progression. In this report, we aimed to identify novel serum-based biomarkers for DM1 through high-throughput next-generation sequencing. A number of miRNAs were identified that are able to distinguish DM1 patients from healthy individuals. Two miRNAs were selected, and their association with the disease was validated in a larger panel of patients. Further investi

SUBMITTER: Koutalianos D 

PROVIDER: S-EPMC8517008 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature