Transcriptomics of chicken cecal tonsils and intestine after infection with low pathogenic avian influenza virus H9N2.

ABSTRACT: Influenza viruses cause severe respiratory infections in humans and birds, triggering global health concerns and economic burden. Influenza infection is a dynamic process involving complex biological host responses. The objective of this study was to illustrate global biological processes in ileum and cecal tonsils at early time points after chickens were infected with low pathogenic avian influenza virus (LPAIV) H9N2 through transcriptome analysis. Total RNA isolated from ileum and cecal tonsils of non-infected and infected layers at 12-, 24- and 72-h post-infection (hpi) was used for mRNA sequencing analyses to characterize differentially expressed genes and overrepresented pathways. Statistical analysis highlighted transcriptomic signatures significantly occurring 24 and 72 hpi, but not

SUBMITTER: Alqazlan N 

PROVIDER: S-EPMC8517014 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature