A treatment planning study of urethra-sparing intensity-modulated proton therapy for localized prostate cancer.

ABSTRACT:

Background and purpose

Urethra-sparing radiation therapy for localized prostate cancer can reduce the risk of radiation-induced genitourinary toxicity by intentionally underdosing the periurethral transitional zone. We aimed to compare the clinical impact of a urethra-sparing intensity-modulated proton therapy (US-IMPT) plan with that of conventional clinical plans without urethral dose reduction.

Materials and methods

This study included 13 patients who had undergone proton beam therapy. The prescribed dose was 63 GyE in 21 fractions for 99% of the clinical target volume. To compare the clinical impact of the US-IMPT plan with that of the conventional clinical plan, tumor control probability (TCP) and normal tissue complication probability (NTCP) were calculated with a gene

SUBMITTER: Yoshimura T 

PROVIDER: S-EPMC8517200 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature