Age-related decline in murine heart and skeletal muscle performance is attenuated by reduced Ahnak1 expression.

ABSTRACT:

Background

Aging is associated with a progressive reduction in cellular function leading to poor health and loss of physical performance. Mitochondrial dysfunction is one of the hallmarks of aging; hence, interventions targeting mitochondrial dysfunction have the potential to provide preventive and therapeutic benefits to elderly individuals. Meta-analyses of age-related gene expression profiles showed that the expression of Ahnak1, a protein regulating several signal-transduction pathways including metabolic homeostasis, is increased with age, which is associated with low VO_2MAX and poor muscle fitness. However, the role of Ahnak1 in the aging process remained unknown. Here, we investigated the age-related role of Ahnak1 in murine exercise capacity, mitochondrial functi

SUBMITTER: Mahmoodzadeh S 

PROVIDER: S-EPMC8517348 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature