Physiologic and molecular characterization of a novel murine model of metastatic head and neck cancer cachexia.

ABSTRACT:

Background

Cancer cachexia is a metabolic disorder characterized by the progressive loss of fat and lean mass that results in significant wasting, ultimately leading to reduced quality of life and increased mortality. Effective therapies for cachexia are lacking, potentially owing to the mismatch in clinically relevant models of cachexia. Specifically, cachexia observed in a clinical setting is commonly associated with advanced or late-stage cancers that are metastatic, yet pre-clinical metastatic models of cachexia are limited. Furthermore, the prevalence of cachexia in head and neck cancer patients is high, yet few pre-clinical models of head and neck cancer cachexia exist. In addition to these shortcomings, cachexia is also heterogeneous among any given cancer, whereas patients

SUBMITTER: Olson B 

PROVIDER: S-EPMC8517353 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature