Growth hormone secretagogue receptor-1a mediates ghrelin's effects on attenuating tumour-induced loss of muscle strength but not muscle mass.

ABSTRACT:

Background

Ghrelin may ameliorate cancer cachexia (CC) by preventing anorexia, muscle, and fat loss. However, the mechanisms mediating these effects are not fully understood. This study characterizes the pathways involved in muscle mass and strength loss in the Lewis lung carcinoma (LLC)-induced cachexia model, and the effects of ghrelin in mice with or without its only known receptor: the growth hormone secretagogue receptor-1a ((GHSR-1a), Ghsr^+/+ and Ghsr^-/- ).

Methods

Five to 7-month-old male C57BL/6J Ghsr^+/+ and Ghsr^-/- mice were inoculated with 1 × 10⁶ heat-killed (HK) or live LLC cells (tumour implantation, TI). When tumours were palpable (7 days after TI), tumour-bearing mice were injected with vehicle (T + V) or

SUBMITTER: Liu H 

PROVIDER: S-EPMC8517358 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature