Predictive impact of sarcopenia in solid cancers treated with immune checkpoint inhibitors: a meta-analysis.

ABSTRACT: Sarcopenia, which is characterized by a decrease in muscle quantity or quality, is commonly observed in patients with cancer. Recent research has reported contradictory results on the association between sarcopenia and the efficacy of immune checkpoint inhibitors (ICIs). We conducted a systematic review and meta-analysis to investigate this discrepancy. We systematically searched three electronic databases to identify articles reporting on the association between sarcopenia and treatment outcomes in patients with solid cancers who received ICIs. The outcomes assessed were hazard ratios (HRs) for overall survival (OS) and progression-free survival (PFS), and odds ratios (ORs) for objective response rate (ORR), disease control rate (DCR), and toxicity. Pooled estimates and their 95% confiden

SUBMITTER: Takenaka Y 

PROVIDER: S-EPMC8517360 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature