Matrisome, innervation and oxidative metabolism affected in older compared with younger males with similar physical activity.

ABSTRACT:

Background

Due to the interaction between skeletal muscle ageing and lifestyle factors, it is often challenging to attribute the decline in muscle mass and quality to either changes in lifestyle or to advancing age itself. Because many of the physiological factors affecting muscle mass and quality are modulated by physical activity and physical activity declines with age, the aim of this study is to better understand the effects of early ageing on muscle function by comparing a population of healthy older and young males with similar physical activity patterns.

Methods

Eighteen older (69 ± 2.0 years) and 20 young (22 ± 2.0 years) males were recruited based on similar self-reported physical activity, which was verified using accelerometry measurements. Gene expression profile

SUBMITTER: Lagerwaard B 

PROVIDER: S-EPMC8517362 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature