Ontology highlight
ABSTRACT:
SUBMITTER: Sun M
PROVIDER: S-EPMC8517388 | biostudies-literature | 2021 Oct
REPOSITORIES: biostudies-literature
Sun Meng M Zhang Helin H Jiang Min M Chai Yan Y Qi Jianxun J Gao George F GF Tan Shuguang S
iScience 20210930 10
Human trophoblast cell surface antigen 2 (TROP-2) is an important target of tumor therapy, and antibody-drug conjugates with sacituzumab targeting TROP-2 have been approved for the treatment of triple-negative breast cancer. Here, we report the crystal structures of TROP-2-ECD, which can be either <i>cis-</i> or <i>trans-</i>dimers depending on which distinct but overlapping interfaces is used to engage with monomers. The <i>cis-</i> or <i>trans</i>-tetrameric forms of TROP-2 can also be assembl ...[more]