Transcriptomic Profiles in Children With Septic Shock With or Without Immunoparalysis.

ABSTRACT:

Background

Severe innate immune suppression, termed immunoparalysis, is associated with increased risks of nosocomial infection and mortality in children with septic shock. Currently, immunoparalysis cannot be clinically diagnosed in children, and mechanisms remain unclear. Transcriptomic studies identify subsets of septic children with downregulation of genes within adaptive immune pathways, but assays of immune function have not been performed as part of these studies, and little is known about transcriptomic profiles of children with immunoparalysis.

Methods

We performed a nested case-control study to identify differences in RNA expression patterns between children with septic shock with immunoparalysis (defined as lipopolysaccharide (LPS)-induced tumor necrosis factor (T

SUBMITTER: Snyder A 

PROVIDER: S-EPMC8517409 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature