Characterization of a bla_NDM-1-Bearing IncHI5-Like Plasmid From Klebsiella pneumoniae of Infant Origin.

ABSTRACT: The spread of plasmid-mediated carbapenem-resistant clinical isolates is a serious threat to global health. In this study, an emerging NDM-encoding IncHI5-like plasmid from Klebsiella pneumoniae of infant patient origin was characterized, and the plasmid was compared to the available IncHI5-like plasmids to better understand the genetic composition and evolution of this emerging plasmid. Clinical isolate C39 was identified as K. pneumoniae and belonged to the ST37 and KL15 serotype. Whole genome sequencing (WGS) and analysis revealed that it harbored two plasmids, one of which was a large IncHI5-like plasmid pC39-334kb encoding a wide variety of antimicrobial resistance genes clustered in a single multidrug resistance (MDR) region. The bla_NDM-1 gene was loca

SUBMITTER: Liu Z 

PROVIDER: S-EPMC8517479 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature