First-In-Human Study in Cancer Patients Establishing the Feasibility of Oxygen Measurements in Tumors Using Electron Paramagnetic Resonance With the OxyChip.

ABSTRACT:

Objective

The overall objective of this clinical study was to validate an implantable oxygen sensor, called the 'OxyChip', as a clinically feasible technology that would allow individualized tumor-oxygen assessments in cancer patients prior to and during hypoxia-modification interventions such as hyperoxygen breathing.

Methods

Patients with any solid tumor at ≤3-cm depth from the skin-surface scheduled to undergo surgical resection (with or without neoadjuvant therapy) were considered eligible for the study. The OxyChip was implanted in the tumor and subsequently removed during standard-of-care surgery. Partial pressure of oxygen (pO₂) at the implant location was assessed using electron paramagnetic resonance (EPR) oximetry.

Results

Twenty-three cancer pati

SUBMITTER: Schaner PE 

PROVIDER: S-EPMC8517507 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature