Identification of CDCA2 as a Diagnostic and Prognostic Marker for Hepatocellular Carcinoma.

ABSTRACT:

Objective

Hepatocellular carcinoma (HCC) is one of the most common and malignant tumors with an insidious onset, difficult early diagnosis, and limited therapy options, resulting in a poor prognosis. Cell division cycle associated 2 (CDCA2), also known as Repo-Man, plays an important role in regulating mitosis and DNA repair, but the involvement of CDCA2 in HCC remains unclear.

Methods

The differentially expressed genes that were significantly upregulated in multiple RNA sequencing datasets of HCC were screened. Receiver operating characteristic (ROC) curve analysis was performed to identify diagnostic markers for HCC. Least absolute shrinkage and selection operator Cox regression analysis was performed to screen the prognosis-related genes. The screening and analyses identi

SUBMITTER: Yu Z 

PROVIDER: S-EPMC8517522 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature