Non-invasive biomarkers of Fontan-associated liver disease.

ABSTRACT:

Background & aims

Fontan-associated liver disease (FALD) has emerged as an important morbidity following surgical palliation of single ventricle congenital heart disease. In this study, non-invasive biomarkers that may be associated with severity of FALD were explored.

Methods

A retrospective cohort of paediatric patients post-Fontan who underwent liver biopsy at a high volume at a paediatric congenital heart disease centre was reviewed.

Results

Among 106 patients, 66% were male and 69% were Hispanic. The mean age was 14.4 ± 3.5 years, and biopsy was performed 10.8 ± 3.6 years post-Fontan. The mean BMI was 20.8 ± 5 kg/m², with 27.4% meeting obesity criteria. Bridging fibrosis was observed in 35% of patients, and 10.4% of all patients had superimposed steato

SUBMITTER: Emamaullee J 

PROVIDER: S-EPMC8517550 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature