Osteochondral tissue engineering: Perspectives for clinical application and preclinical development.

ABSTRACT: The treatment of osteochondral defects (OCD) remains challenging. Among currently available surgical treatments for OCDs, scaffold-based treatments are promising to regenerate the osteochondral unit. However, there is still no consensus regarding the clinical effectiveness of these scaffold-based therapies for OCDs. Previous reviews have described the gradient physiological characteristics of osteochondral tissue and gradient scaffold design for OCD, tissue engineering strategies, biomaterials, and fabrication technologies. However, the discussion on bridging the gap between the clinical need and preclinical research is still limited, on which we focus in the present review, providing an insight into what is currently lacking in tissue engineering methods that failed to yield satisfactory

SUBMITTER: Ai C 

PROVIDER: S-EPMC8517716 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature