Modification of innate immune responses to Bordetella pertussis in babies from pertussis vaccinated pregnancies.

ABSTRACT:

Background

Tetanus, diphtheria, acellular pertussis, inactivated polio (Tdap-IPV) vaccines administered during pregnancy protect young infants from Bordetella pertussis (B. pertussis) infection. Whilst the impact of maternal Tdap-IPV vaccination on infants' humoral response to subsequent pertussis immunisation has been investigated, little is known about any impact on innate responses.

Methods

We investigated the immune response to B. pertussis in mothers and infants from Tdap-IPV-vaccinated and unvaccinated pregnancies, utilising a whole blood assay and flow cytometric phenotyping of neonatal natural killer (NK) cells, monocytes and dendritic cells. Blood was collected from mother and umbilical cord at birth, and from infants at seven weeks (one week pre-primary pertussis i

SUBMITTER: Rice TF 

PROVIDER: S-EPMC8517834 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature