Imaging cortical multiple sclerosis lesions with ultra-high field MRI.

ABSTRACT:

Background

Cortical lesions are abundant in multiple sclerosis (MS), yet difficult to visualize in vivo. Ultra-high field (UHF) MRI at 7 T and above provides technological advances suited to optimize the detection of cortical lesions in MS.

Purpose

To provide a narrative and quantitative systematic review of the literature on UHF MRI of cortical lesions in MS.

Methods

A systematic search of all literature on UHF MRI of cortical lesions in MS published before September 2020. Quantitative outcome measures included cortical lesion numbers reported using 3 T and 7 T MRI and between 7 T MRI sequences, along with sensitivity of UHF MRI towards cortical lesions verified by histopathology.

Results

7 T MRI detected on average 52 ± 26% (mean ± 95% confidence interval) mo

SUBMITTER: Madsen MAJ 

PROVIDER: S-EPMC8517925 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature