On the origin of the genetic variation in infectious disease prevalence: Genetic analysis of disease status versus infections for Digital Dermatitis in Dutch dairy cattle.

ABSTRACT: The purpose of this study was to investigate the origin of the genetic variation in the prevalence of bovine digital dermatitis (DD) by comparing a genetic analysis of infection events to a genetic analysis of disease status. DD is an important endemic infectious disease affecting the claws of cattle. For disease status, we analysed binary data on individual disease status (0,1; indicating being free versus infected), whereas for infections, we analysed binary data on disease transmission events (1,0; indicating becoming infected or not). The analyses of the two traits were compared using cross-validation. The analysis of disease status captures a combination of genetic variation in disease susceptibility and the ability of individuals to recover, whereas the analysis of infections capture

SUBMITTER: Kulkarni PS 

PROVIDER: S-EPMC8518086 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature