Na⁺-dependent inactivation of vascular Na⁺/Ca²⁺ exchanger responsible for reduced peripheral blood flow in neuropathic pain model.

ABSTRACT: Reduced skin blood flow has been reported in neuropathic pain patients as well as various peripheral neuropathic pain model animals. We have previously shown that vasodilators, which improves reduced skin blood flow, correlatively alleviate neuropathic pain in chronic constriction injury (CCI) mice, a model of neuropathic pain from peripheral nerve injury. Here, we sought to elucidate the mechanism underlying the reduced skin blood flow in CCI rats. The skin blood flow of the ipsilateral plantar arteries was significantly reduced compared to that of the contralateral ones 4 weeks after loose ligation of the sciatic nerve. The contraction induced by noradrenaline, serotonin, and U46619, a thromboxane receptor agonist, in the isolated ipsilateral plantar arteries was significantly enhanced c

SUBMITTER: Ishida H 

PROVIDER: S-EPMC8518190 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature