A Novel Stability-Indicating HPLC-DAD Method for Determination of Favipiravir, a Potential Antiviral Drug for COVID-19 Treatment; Application to Degradation Kinetic Studies and In-Vitro Dissolution Profiling.

ABSTRACT: Modern pharmaceutical analysis is paying a lot of attention to the stability of novel drug formulations as well as establishment of suitable stability-indicating approaches. In the current work, a comprehensive stability-indicating HPLC-DAD method has been developed and validated for determination of favipiravir (FAV) which is a novel and emerging antiviral option in COVID-19 treatment. The stability of FAV was examined under different stress conditions. FAV was found to be susceptible to acid, base hydrolysis and oxidative degradation. Structure elucidation of the forced degradation products was carried out using mass spectrometry (MS) operated in electrospray ionization mode. Effective separation of FAV and its induced degradation products was achieved using isocratic elution mode on Zor

SUBMITTER: Marzouk HM 

PROVIDER: S-EPMC8518200 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature