First trimester exposure to ambient gaseous air pollutants and risk of orofacial clefts: a case-control study in Changsha, China.

ABSTRACT:

Background

A growing body of studies have investigated the association between air pollution exposure during early pregnancy and the risk of orofacial clefts, but these studies put more emphasis on particulate matter and reported inconsistent results, while research on the independent effects of gaseous air pollutants on orofacial clefts has been quite inadequate, especially in China.

Methods

A case-control study was conducted in Changsha, China from 2015 to 2018. A total of 446 cases and 4460 controls were included in the study. Daily concentrations of CO, NO₂, SO₂, O₃, PM_2.5 and PM₁₀ during the first trimester of pregnancy were assigned to each subject using the nearest monitoring station method. Multivariate logistic

SUBMITTER: Jiang W 

PROVIDER: S-EPMC8518237 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature