Identification of long noncoding RNAs in injury-resilient and injury-susceptible mouse retinal ganglion cells.

ABSTRACT:

Background

Emerging evidence indicates that long noncoding RNAs (lncRNAs) are important regulators of various biological processes, and their expression can be altered following certain pathological conditions, including central nervous system injury. Retinal ganglion cells (RGCs), whose axons form the optic nerve, are a heterogeneous population of neurons with more than 40 molecularly distinct subtypes in mouse. While most RGCs, including the ON-OFF direction-selective RGCs (ooDSGCs), are vulnerable to axonal injury, a small population of RGCs, including the intrinsically photosensitive RGCs (ipRGCs), are more resilient.

Results

By performing systematic analyses on RNA-sequencing data, here we identify lncRNAs that are expressed in ooDSGCs and ipRGCs with and without axonal

SUBMITTER: Ayupe AC 

PROVIDER: S-EPMC8518251 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature