Does a lack of vaccine side effects correlate with reduced BNT162b2 mRNA vaccine response among healthcare workers and nursing home residents?

ABSTRACT:

Background

The BNT162b2 SARS-CoV-2 mRNA vaccination has mitigated the burden of COVID-19 among residents of long-term care facilities considerably, despite being excluded from the vaccine trials. Data on reactogenicity (vaccine side effects) in this population are limited.

Aims

To assess reactogenicity among nursing home (NH) residents. To provide a plausible proxy for predicting vaccine response among this population.

Methods

We enrolled and sampled NH residents and community-dwelling healthcare workers who received the BNT162b2 mRNA vaccine, to assess local or systemic reactogenicity and antibody levels (immunogenicity).

Results

NH residents reported reactions at a much lower frequency and lesser severity than the community-dwelling healthcare workers. These

SUBMITTER: Oyebanji OA 

PROVIDER: S-EPMC8518269 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature