Comparison of resting-state EEG between adults with Down syndrome and typically developing controls.

ABSTRACT:

Background

Down syndrome (DS) is the most common genetic cause of intellectual disability (ID) worldwide. Understanding electrophysiological characteristics associated with DS provides potential mechanistic insights into ID, helping inform biomarkers and targets for intervention. Currently, electrophysiological characteristics associated with DS remain unclear due to methodological differences between studies and inadequate controls for cognitive decline as a potential cofounder.

Methods

Eyes-closed resting-state EEG measures (specifically delta, theta, alpha, and beta absolute and relative powers, and alpha peak amplitude, frequency and frequency variance) in occipital and frontal regions were compared between adults with DS (with no diagnosis of dementia or evidence of cog

SUBMITTER: Hamburg S 

PROVIDER: S-EPMC8518326 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature