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Mechanistic Aspects of the Palladium-Catalyzed Suzuki-Miyaura Cross-Coupling Reaction.

ABSTRACT: The story of C-C bond formation includes several reactions, and surely Suzuki-Miyaura is among the most outstanding ones. Herein, a brief historical overview of insights regarding the reaction mechanism is provided. In particular, the formation of the catalytically active species is probably the main concern, thus the preactivation is in competition with, or even assumes the role of the rate determining step (rds) of the overall reaction. Computational chemistry is key in identifying the rds and thus leading to milder conditions on an experimental level by means of predictive catalysis.

SUBMITTER: D'Alterio MC 

PROVIDER: S-EPMC8518397 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature

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Mechanistic Aspects of the Palladium-Catalyzed Suzuki-Miyaura Cross-Coupling Reaction.

D'Alterio Massimo C MC   Casals-Cruañas Èric È   Tzouras Nikolaos V NV   Talarico Giovanni G   Nolan Steven P SP   Poater Albert A  

Chemistry (Weinheim an der Bergstrasse, Germany) 20210809 54

The story of C-C bond formation includes several reactions, and surely Suzuki-Miyaura is among the most outstanding ones. Herein, a brief historical overview of insights regarding the reaction mechanism is provided. In particular, the formation of the catalytically active species is probably the main concern, thus the preactivation is in competition with, or even assumes the role of the rate determining step (rds) of the overall reaction. Computational chemistry is key in identifying the rds and  ...[more]

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