Determination of Effective Albumin in Patients With Decompensated Cirrhosis: Clinical and Prognostic Implications.

ABSTRACT:

Background and aims

Circulating albumin in cirrhosis can be dysfunctional because of accumulating structural damages, leading to the concept of effective albumin concentration (eAlb), referring to the albumin portion presenting structural and functional integrity. We aimed to estimate eAlb in patients with decompensated cirrhosis and analyze its relationships with albumin function and clinical outcomes as compared to total albumin concentration (tAlb).

Approach and results

We evaluated 319 patients with cirrhosis hospitalized for acute decompensation (AD) with and without acute-on-chronic liver failure (ACLF) and 18 age- and sex-comparable outpatients with compensated cirrhosis. tAlb was quantified by standard assay, whereas eAlb was estimated combining liquid chromatography

SUBMITTER: Baldassarre M 

PROVIDER: S-EPMC8518406 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature