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Catalyst Deactivation During Rhodium Complex-Catalyzed Propargylic C-H Activation.

ABSTRACT: Detailed mechanistic investigations on our previously reported synthesis of branched allylic esters by the rhodium complex-catalyzed propargylic C-H activation have been carried out. Based on initial mechanistic studies, we present herein more detailed investigations of the reaction mechanism. For this, various analytical (NMR, X-ray crystal structure analysis, Raman) and kinetic methods were used to characterize the formation of intermediates under the reaction conditions. The knowledge obtained by this was used to further optimize the previous conditions and generate a more active catalytic system.

SUBMITTER: Moller S

PROVIDER: S-EPMC8518492 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature

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Catalyst Deactivation During Rhodium Complex-Catalyzed Propargylic C-H Activation.

Möller Saskia S Jannsen Nora N Rüger Julia J Drexler Hans-Joachim HJ Horstmann Moritz M Bauer Felix F Breit Bernhard B Heller Detlef D

Chemistry (Weinheim an der Bergstrasse, Germany) 20210801 56

Detailed mechanistic investigations on our previously reported synthesis of branched allylic esters by the rhodium complex-catalyzed propargylic C-H activation have been carried out. Based on initial mechanistic studies, we present herein more detailed investigations of the reaction mechanism. For this, various analytical (NMR, X-ray crystal structure analysis, Raman) and kinetic methods were used to characterize the formation of intermediates under the reaction conditions. The knowledge obtaine ...[more]

PMID: 34260787

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