Iron(II)-Catalyzed Aerobic Biomimetic Oxidation of N-Heterocycles.

ABSTRACT: Herein, an iron(II)-catalyzed biomimetic oxidation of N-heterocycles under aerobic conditions is described. The dehydrogenation process, involving several electron-transfer steps, is inspired by oxidations occurring in the respiratory chain. An environmentally friendly and inexpensive iron catalyst together with a hydroquinone/cobalt Schiff base hybrid catalyst as electron-transfer mediator were used for the substrate-selective dehydrogenation reaction of various N-heterocycles. The method shows a broad substrate scope and delivers important heterocycles in good-to-excellent yields.

SUBMITTER: Manna S 

PROVIDER: S-EPMC8518507 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature