Controlling Coagulation in Blood with Red Light.

ABSTRACT: Precise control of blood clotting and rapid reversal of anticoagulation are essential in many clinical situations. We were successful in modifying a thrombin-binding aptamer with a red-light photocleavable linker derived from Cy7 by Cu-catalyzed Click chemistry. We were able to show that we can successfully deactivate the modified aptamer with red light (660 nm) even in human blood-restoring the blood's natural coagulation capability.

SUBMITTER: Muller P 

PROVIDER: S-EPMC8518524 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature