RT-QuIC Detection of Pathological α-Synuclein in Skin Punches of Patients with Lewy Body Disease.

ABSTRACT:

Background

Evidence suggests that skin represents a suitable matrix for demonstrating α-synuclein oligomers as a diagnostic biomarker for Lewy body disease.

Objective

The objective of this study was to evaluate the diagnostic performance of skin α-syn real-time quaking-induced conversion assay in patients with Lewy body disease.

Methods

We analyzed skin punches taken in vitam (n = 69) or postmortem (n = 49) from patients with PD, dementia with Lew bodies (DLB), incidental Lewy body pathology, and neurological controls. Seventy-nine patients underwent both CSF and skin α-synuclein real-time quaking-induced conversion assay.

Results

Overall, the skin α-synuclein real-time quaking-induced conversion assay distinguished Lewy body disease patients with 94.1% accurac

SUBMITTER: Mammana A 

PROVIDER: S-EPMC8518528 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature