A Water Soluble Pd₂ L₄ Cage for Selective Binding of Neu5Ac.

ABSTRACT: The sialic acid N-acetylneuraminic acid (Neu5Ac) and its derivatives are involved in many biological processes including cell-cell recognition and infection by influenza. Molecules that can recognize Neu5Ac might thus be exploited to intervene in or monitor such events. A key obstacle in this development is the sparse availability of easily prepared molecules that bind to this carbohydrate in its natural solvent; water. Here, we report that the carbohydrate binding pocket of an organic soluble [Pd₂ L₄ ]⁴⁺ cage could be equipped with guanidinium-terminating dendrons to give the water soluble [Pd₂ L₄ ][NO₃ ]₁₆ cage 7. It was shown by means of NMR spectroscopy that 7 binds selectively to anionic monosaccharides and s

SUBMITTER: Schaapkens X 

PROVIDER: S-EPMC8518546 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature