Selective Electrosynthetic Hydrocarboxylation of α,β-Unsaturated Esters with Carbon Dioxide*.

ABSTRACT: The carboxylation of low-value commodity chemicals to provide higher-value carboxylic acids is of significant interest. Recently alternative routes to the traditional hydroformylation processes that used potentially toxic carbon monoxide and a transition metal catalyst have appeared. A significant challenge has been the selectivity observed for olefin carboxylation. Photochemical methods have shown a viable route towards the hydrocarboxylation of α,β-unsaturated alkenes but rely on the use of an excess reducing or amine reagent. Herein we report our investigations of an electrochemical approach that is able to hydrocarboxylate α,β-unsaturated alkenes with excellent regioselectivity and the ability to carboxylate hindered substrates to afford α-quaternary center carboxylic acids. The report

SUBMITTER: Sheta AM 

PROVIDER: S-EPMC8518608 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature