Accuracy of Transient Elastography in Assessing Fibrosis at Diagnosis in Naive Patients With Primary Biliary Cholangitis: A Dual Cut-Off Approach.

ABSTRACT:

Background and aims

Liver fibrosis holds a relevant prognostic meaning in primary biliary cholangitis (PBC). Noninvasive fibrosis evaluation using vibration-controlled transient elastography (VCTE) is routinely performed. However, there is limited evidence on its accuracy at diagnosis in PBC. We aimed to estimate the diagnostic accuracy of VCTE in assessing advanced fibrosis (AF) at disease presentation in PBC.

Approach and results

We collected data from 167 consecutive treatment-naïve PBC patients who underwent liver biopsy (LB) at diagnosis at six Italian centers. VCTE examinations were completed within 12 weeks of LB. Biopsies were scored by two blinded expert pathologists, according to the Ludwig system. Diagnostic accuracy was estimated using the area under the receiver

SUBMITTER: Cristoferi L 

PROVIDER: S-EPMC8518641 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature