On the diversity of F₄₂₀ -dependent oxidoreductases: A sequence- and structure-based classification.

ABSTRACT: The F₄₂₀ deazaflavin cofactor is an intriguing molecule as it structurally resembles the canonical flavin cofactor, although behaves as a nicotinamide cofactor due to its obligate hydride-transfer reactivity and similar low redox potential. Since its discovery, numerous enzymes relying on it have been described. The known deazaflavoproteins are taxonomically restricted to Archaea and Bacteria. The biochemistry of the deazaflavoenzymes is diverse and they exhibit great structural variability. In this study a thorough sequence and structural homology evolutionary analysis was performed in order to generate an overarching classification of the F₄₂₀ -dependent oxidoreductases. Five different deazaflavoenzyme Classes (I-V) are described according to their structural folds

SUBMITTER: Mascotti ML 

PROVIDER: S-EPMC8518648 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature