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{BiW8 O30 } Exerts Antitumor Effect by Triggering Pyroptosis and Upregulating Reactive Oxygen Species.

ABSTRACT: We successfully synthesized {BiW8 }, a 10-nuclear heteroatom cluster modified {BiW8 O30 }. At 24 h post-incubation, the IC50 values of {BiW8 } against HUVEC, MG63, RD, Hep3B, HepG2, and MCF7 cells were 895.8, 127.3, 344.3, 455.0, 781.3, and 206.3 μM, respectively. The IC50 value of {BiW8 } on the MG63 cells was more than 2-fold lower than that of the other raw materials. Through morphological and functional features, we demonstrated pyroptosis as a newly identified mechanism of cell death induced by {BiW8 }. {BiW8 } increased 2-fold reactive oxygen species (ROS) levels in MG63 cells at 24 h post-incubation. Compared with 0 h, the glutathione (GSH) content decreased by 59, 65, 75, 94, and 97 % at 6, 12, 24, 36 and 48 h post-incubation, respectively. Furthermore, multiple antitumor mechanisms of {BiW8 } were identified via transcriptome analysis and chemical simulation, including activation of pyroptosis, suppression of GSH generation, depletion of GSH, and inhibition of DNA repair.

SUBMITTER: Jia D 

PROVIDER: S-EPMC8518649 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature

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{BiW<sub>8</sub> O<sub>30</sub> } Exerts Antitumor Effect by Triggering Pyroptosis and Upregulating Reactive Oxygen Species.

Jia Di D   Gong Lige L   Li Ying Y   Cao Shu S   Zhao Weiming W   Hao Lijun L   Li Shasha S   Pang Bo B   Zhang Chunjing C   Li Shuyan S   Zhang Wei W   Chen Tianyi T   Dong Limin L   Zhou Baibin B   Yang Dan D  

Angewandte Chemie (International ed. in English) 20210820 39

We successfully synthesized {BiW<sub>8</sub> }, a 10-nuclear heteroatom cluster modified {BiW<sub>8</sub> O<sub>30</sub> }. At 24 h post-incubation, the IC<sub>50</sub> values of {BiW<sub>8</sub> } against HUVEC, MG63, RD, Hep3B, HepG2, and MCF7 cells were 895.8, 127.3, 344.3, 455.0, 781.3, and 206.3 μM, respectively. The IC<sub>50</sub> value of {BiW<sub>8</sub> } on the MG63 cells was more than 2-fold lower than that of the other raw materials. Through morphological and functional features, we  ...[more]

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