The association of maternal folic acid supplementation and prenatal folate and vitamin B12 concentrations with child dental development.

ABSTRACT:

Objective

Low folic acid, folate and vitamin B12 might affect tooth formation and mineralization. The conversion of folic acid into folate is catalysed by the methylenetetrahydrofolate (MTHFR) enzyme which is encoded by the MTHFR gene. Among 3728 mothers and their 10-year-old children from the Generation R Study, we investigated associations of maternal folic acid supplementation and prenatal folate and vitamin B12 concentrations with child dental development. Secondly, we checked the modifying effect of MTHFR-C677T polymorphism.

Methods

Information on folic acid supplementation was obtained by questionnaires. Concentrations of folate and vitamin B12 were measured from venous samples taken in early pregnancy. Developmental stages of teeth were defined by the Demirjian method

SUBMITTER: Dhamo B 

PROVIDER: S-EPMC8518742 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature